Association between with or without Non-alcoholic fatty liver with diabetic retinopathy in type 2 diabetic mellitus patients
10.3760/cma.j.issn.1008-6315.2016.08.005
- VernacularTitle:2型糖尿病合并或未合并非酒精性脂肪性肝病与糖尿病视网膜病变的相关性
- Author:
Yilu ZHANG
;
Jing YANG
;
Na AO
;
Fengying LI
;
Jian DU
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Non-alcoholic fatty liver disease;
Diabetic retinopathy
- From:
Clinical Medicine of China
2016;32(8):687-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between with or without non?alcoholic fatty liver disease(NAFLD) and diabetic retinopathy(DR) in type 2 diabetes mellitus(T2DM)?Methods Clinical and laboratorial data of 517 cases T2DM hospitalized patients were collected,and the patients were divided into two groups according to if the NAFLD was complicated or not?Group A was T2DM with NAFLD and group B was T2DM without NAFLD?The general information and the laboratorial checking results were Compared, then various index were used as the independent variable, DR was used as the dependent variable for Logistic regression analysis?Results (1)In the 517 cases of T2DM patients,the incorporative rate of the NAFLD was 65?7%(349/517)?(2)Compared with group B,the levels of body mass index(BMI),insulin resistance index (HOMA?IR),glutamyltransferase(GGT),alanine aminotransferase(ALT),aspartate aminotransferase(AST), triglyceride(TG),total cholesterol(TC),low?density lipoprotein cholesterol(LDL?C) and uric acid(UA) for group A were significantly increased, while the high?density lipoprotein cholesterol ( HDL?C ) level was significantly decreased?All the differences were statistically significant( P<0?05)?( 3) Logistic analysis showed that the duration of the extension,hypertension,the increasing level of NAFLD,LDL?C were the risk factors of DR?Even though excluded the influence of duration,high blood pressure and LDL?C level,NAFLD was still the risk factor for T2DM complicated by the DR( OR=2?176,95% CI ( 1?354,3?199) )?Conclusion NAFLD and DR are closely related, so early diagnosis and intervention of NAFLD may prevent the occurrence and development of DR.
