Treatment effect of gonadotropin releasing hormone agonist-a different drug consolidation therapy time on endometriosis patients received endometriosis laparoscopic surgery
10.3760/cma.j.issn.1008-6315.2016.08.019
- VernacularTitle:促性腺激素释放激素激动剂a不同药物巩固时间对子宫内膜异位症腹腔镜手术治疗效果影响
- Author:
Jing LI
;
Tao HOU
;
Hui LIANG
;
Shifen DAI
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Gonadotropin releasing hormone agonist;
Estrogen;
Inflammatory reaction
- From:
Clinical Medicine of China
2016;32(8):735-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the treatment effect of gonadotropin releasing hormone agonist?α( GnRH?α) different drug consolidation therapy time on endometriosis patients received endometriosis laparoscopic surgery?Methods Seventy cases endometriosis patients received endometriosis laparoscopic surgery in the People's Hospital of Meizhou from May 2012 to March 2014 were enrolled for study and randomly divided into 6 months group and 3 months group according to different time of GnRH?αtreatment?Then hormone levels, inflammatory mediators, follow?up condition and treatment outcome were compared between the two groups?Results The total effective rate of 6 months group was 97?14%( 34/35) ,significantly higher than that of 3 months group(80?00%(28/35)),the difference was significant(χ2 =5?081,P<0?05)?Serum follicle stimulating hormone( FSH) ,progesterone( LH) ,estradiol( E2) levels of 6 months group were significantly lower than 3 months group,the differences were significant((2?42±0?33) U/L vs?(3?79±0?42),(3?49±0?45) U/L vs?(5?12±0?60) U/L,(89?48±10?23) ng/L vs? (130?48±16?85) ng/L;t=15?174,12?858,12?305;P<0?05)?Serum TNF?α,IL?6,IL?8 levels of 6 months group were significantly lower than 3 months group,the differences were significant((18?48±2?23) ng/L vs?(31?49±4?05) ng/L,(14?45±2?18) ng/L vs?(23?49 ±2?95) ng/L,(35?29±4?52) ng/L vs? (58?49±7?28) ng/L;t=16?648,14?580,16?017;P<0?05)?The pregnancy rate,pain relief rate of 6 months group were significantly higher than 3 months group(51?43%(18/35) vs?22?86%(8/35),74?29%(26/35) vs?40?00%(14/35)),the recurrence rate was significantly lower than that 3 months group(8?57%(3/35) vs?31?43%(11/35)),the differences were significant(χ2=6?118, 8?400,5?714;P<0?05)?Conclusion 6 months GnRH?α treatment after laparoscopic surgery help to prevent disease relapse,and regulate hormone levels,inhibit inflammatory reaction,then improve the effect of treatment.
