When Can We Identify Fetal Male Gene By Using Maternal Plasma DNA?.
- Author:
Soon Choul HONG
1
;
Jun Souk SONG
;
Soo Hun CHO
;
Jae Yoon SONG
;
Seon Young PARK
;
Young Tae KIM
;
Sun Haeng KIM
;
Kyu Wan LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Korea University, Korea.
- Publication Type:Original Article
- Keywords:
Maternal plasma;
Fetal DNA;
SRY gene
- MeSH:
DNA*;
Female;
Fetus;
Genes, sry;
Humans;
Inpatients;
Male*;
Plasma*;
Pregnancy;
Pregnant Women;
Y Chromosome
- From:Korean Journal of Obstetrics and Gynecology
2002;45(1):78-83
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To know when we can identify fetal Y chromosome SRY gene by using fetal DNA in maternal plasma. METHODS: DNA from maternal plasma of 62 pregnant women (48: inpatients, 14: outpatients) underwent a sensitive Y-PCR assay to identify SRY gene of Y chromosome. RESULTS: Of the patients, fetus-derived Y sequences were detected in 37 (88.1%) of the 42 maternal plasma samples from women bearing male fetuses. One of the 20 women bearing female fetuses had positive result from plasma DNA. Seventh gestational week was the earliest gestation of gender identification. CONCLUSION: We could identify fetal gender using fetal DNA in maternal plasma (sensitivity 88.1%). The earlist to detect was 7th gestational week.
