Analysis of high-risk factors of white matter damage in premature infants
10.3760/cma.j.issn.1008-6315.2016.08.020
- VernacularTitle:早产儿脑白质损伤临床高危因素分析
- Author:
Xiaoyu YANG
;
Xianghong LI
;
Lili LEI
;
Dongyun LIU
;
Hong JIANG
- Publication Type:Journal Article
- Keywords:
White matter damage;
Premature;
Risk factors
- From:
Clinical Medicine of China
2016;32(8):739-743
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify high?risk factors of white matter damage ( WMD ) in premature infants,in order to reduce the incidence and improve the prognosis of brain injury?Methods Five hundred and seventy?seven cases of preterm infants treated from January 2012 to December 2013 in the Pediatrics Department of Affiliated Hospital of Qingdao University were slecteted?According to MRI of the brain at 2 weeks after birth, all the patients were divided into WMD group(133 cases) and the control group(444 cases)?Single?factor and multifactor logistic regression were used for the analyses of the high?risk factors of WMD?Results WMD incidence was 23?05%( 133/577) in 577 cases of premature infants,with 108 cases( 81?2%) of focal injury,5 cases(3?8%) of diffuse injury and 20 cases(15?0%) of periventricular leukomalacia(PVL) injury?There was significant statistically difference in different gestational age( P=0?017)?Multi factor Logistic regression analysis showed that metabolic acidosis(OR=4?489,P=0?000),asphyxia(OR=3?519,P=0?000),perinatal infection ( OR=2?650,P=0?003) were independent risk factors for WMD,while cesarean( OR=0?293,P=0?000) was protective factor for WMD?Conclusion WMD is a complex interaction outcome of multiple risk factors in premature infant?Perinatal hypoxia and infection are the main risk factors of WMD in premature infants.
