In vitro activity of tigecycline and minocycline against Van M-type vancomycin-resistantEnterococcus faecium

VernacularTitle:替加环素、米诺环素对VanM型万古霉素耐药屎肠球菌体外抗菌活性
Author: Chunhui CHEN ; Yan GUO ; Shi WU ; Yang YANG ; Fupin HU ; Demei ZHU ; Xiaogang XU
Publication Type:Journal Article
Keywords: tigecycline; minocycline; vancomycin; antibiotic resistance; Enterococcus faecium
From: Chinese Journal of Infection and Chemotherapy 2016;16(3):327-329
CountryChina
Language:Chinese
Abstract: Objective To investigate thein vitro activity of tigecycline and minocycline against VanM-type vancomycin-resistant Enterococcusfaecium.Methods A total of 45 strains of VanM-type vancomycin-resistantE. faecium were obtained from hospitals in Shanghai between 2006 and 2014. Species and vancomycin resistance genotype were identiifed by PCR and sequencing analysis. Minimal inhibitory concentrations (MICs) of ten antimicrobial agents against these strains were determined.Results All the 45 isolates were VanM-type vancomycin-resistantE. faecium, and resistant to vancomycin (MIC: 128 to >256 mg/L). And 71.1%of the strains were resistant to teicoplanin. Almost all isolates showed resistance to levolfoxacin (100%) and ampicillin (97.8%). About 15.6%, 64.4% and 82.2% of the strains were resistant to minocycline, gentamicin and rifampicin, respectively.Conclusion Tigecycline and minocycline exhibit excellentin vitro activity against these VanM-type vancomycin-resistantE. faecium isolates.