Correlation of nuclear-cytoplasmic transport of pRB in the invasive front and lymph node metastasis in papillary thyroid carcinoma
10.3969/j.issn.1006-5725.2016.10.015
- VernacularTitle:甲状腺乳头状癌浸润前沿磷酸化RB核质转位表达与淋巴结转移相关
- Author:
Xiaolan XIAO
;
Wenchuan WU
;
Zhuori LI
;
Chunji CHEN
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasm;
Papillary carcinoma;
RB;
Immunohistochemistry;
Nuclear-cyto-plasmic transport
- From:
The Journal of Practical Medicine
2016;32(10):1602-1605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of phosphorylated RB (pRB) in the invasion front of papillary thyroid carcinoma and the clinical pathological implications. Methods Immunohistochemistry was ap-plied in analyzing pRB expression feature and the clinical pathological implications in a total of 82 patients who underwent total or subtotal thyroidectomy and neck lymph node dissection for papillary thyroid carcinoma. Results The displacement of pRB proteins from the nucleus to the cytoplasm was observed in the invasive front of papil-lary thyroid carcinoma , which was an independent predictor of lymph node metastasis in papillary thyroid carci-noma. Conclusion Nuclear-cytoplasmic transport of pRB in the invasive front was an independent predictor of lymph node metastasis in papillary thyroid carcinoma.
