The role of dexmedetomidinein immune function of patients with breast cancer via sevoflurane inhalation general anesthesia during perioperative radical mastectomy
10.3969/j.issn.1006-5725.2016.10.039
- VernacularTitle:右美托咪定对七氟烷全麻乳腺癌根治术围术期免疫功能的影响
- Author:
Yongmin XU
;
Yanshi FU
;
Yanping ZHENG
;
Lin CHEN
;
Xinming YANG
;
Yan ZHOU
;
Jun CHEN
;
Wanpin WANG
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Sevoflurane;
Breast Cancer;
Radical Mastectomy
- From:
The Journal of Practical Medicine
2016;32(10):1681-1684
- CountryChina
- Language:Chinese
-
Abstract:
Objects To evaluate the immune protective effect of dexmedetomidine on breast cancer dur-ing perioperative radical mastectomy via sevoflurane inhalation general anesthesia. To explore reasonable anesthet-ic strategyfor breast cancer radical mastectomy. Methods Patients were divided into two groups. Patients in ex-perimental group receivedgeneral anesthesia with dexmedetomidine and sevoflurane. Control group means general anesthesia with sevoflurane only. In both groups, the level of cortisol, IL-6, IL-8 and of TNF-αin serum were measured at 5 time points , 30 minutes before anesthesia , after cutting skin , after surgery , 24 h after surgery and 72 h after surgery. Results The amount of anesthetic used to induce general anesthesia in the experimen-talgroup were lower than that of the control group.There is no obvious difference of cortisol , IL-6, IL-8 and of TNF-αin serumat the time of 30 min before anesthesia between two groups.Concentrations ofseveral markersin-creasedafter anesthesia, of which experimentalgroup were lower than that of the control group. Conclusions Dexmedetomidine could be immunoprotective for patient with breast cancer during perioperative radical mastecto-my via sevoflurane inhalationgeneralanesthesia. This study recommends usingmultiple anestheticdrugs to anes-thetize patients of breast cancer when performing radical mastectomy.
