Clinical Value of Serum 14-3-3η protein levels in patients with Rheumatoid Arthritis and Secondary Osteo-porosis

VernacularTitle:血清14-3-3η蛋白水平在类风湿关节炎及其合并骨质疏松中的临床意义
Author: Xun GONG ; Shengqian XU ; Ying WU ; Canchen MA ; Shan QI ; Wen LIU ; Jianhua XU
Publication Type:Journal Article
Keywords: 14-3-3η protein; rheumatoid arthritis; osteoporosis
From: The Journal of Practical Medicine 2016;32(10):1592-1594
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical value of serum 14-3-3η protein levels in patients with rheumatoid arthritis (RA) and secondary osteoporosis (OP). Methods 259 RA patients and 80 healthy controls were recruited. Serum 14-3-3η levels were determined by ELISA and bone mineral density (BMD) were detected by the DEXA. Results Firstly, the levels and the positive rate of serum 14-3-3η protein were significantly high-er in RA patients than healthy controls (P < 0.000 1). Secondly, ROC curve revealed that the sensitivity of 14-3-3η protein for diagnosis of early RA was 91.7% and its specificity was 99.6% when the cut-off point was 0.879 ng/mL (AUC = 0.917, P < 0.000 1). Finally, 14-3-3η protein concentrations revealed significant differ-ence among the groups of bone mass normal, osteopenia and osteoporosis in early RA (χ2=7.974, P = 0.019). Conclusion Serum 14-3-3η protein levels increase significantly in RA , especially in early RA , which is relat-ed to clinical symptoms and osteoporosis.