The Detection and Clinical Value of Soluble Triggering Receptor Expressed on Myeloid Cells-1in Patients with Stable Chronic Obstructive Pulmonary Disease
10.3969/j.issn.1006-5725.2016.10.017
- VernacularTitle:稳定期慢性阻塞性肺疾病患者血清可溶性髓样细胞触发受体－1的检测及临床意义
- Author:
Juan WU
;
Hang SHA
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
inflammation;
soluble triggering receptor expressed on myeloid cells-1
- From:
The Journal of Practical Medicine
2016;32(10):1609-1612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the value of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in patients with stable chronic obstructive pulmonary disease (sCOPD). Methods From 2015 January to 2015 August, 101 patients with stable chronic obstructive pulmonary disease and 81 healthy controls were en-rolled. All subjects underwent pulmonary function test to record FEV1%pred and FEV1%FVC and their serum sTREM-1 levels were determined. Arterial blood gas analyses and COPD assessment tests were also conducted in stable COPD patients. Results Serum sTREM-1 levels were significantly higher in stable COPD patients than healthy controls (113.2 ± 31.5 pg/mL and 83.8 ± 17.9 pg/mL respectively, P=0.000). sTREM-1 levels were posi-tively correlated with CAT score (r=0.507, P=0.000), whereas negatively correlated with FEV1%pred and PaO2 (r = 0.507, P = 0.000; r = 0.439, P = 0.000). Conclusion sTREM-1 is a promising biomarker to evaluate sCOPD in the future.
