Spontaneous ovulation in in vitro fertilization-embryo transfer cycles using gonadotropin-releasing hormone antagonist：a large-sample retrospective study
10.3760/cma.j.issn.0529-567x.2016.05.006
- VernacularTitle:GnRH拮抗剂方案在体外受精-胚胎移植周期中自发排卵风险的大样本量回顾性研究
- Author:
Lu LUO
;
Minghui CHEN
;
Mengxi JIA
;
Qiong WANG
;
Canquan ZHOU
- Publication Type:Journal Article
- Keywords:
Fertilization,in vitro;
Embryo transfer;
Ovulation induction;
Gonadotropin-releasing hormone;
Risk factors;
Clinical protocols;
Retrospective studies
- From:
Chinese Journal of Obstetrics and Gynecology
2016;51(5):352-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the premature spontaneous ovulation rates in in vitro fertilization-embryo transfer (IVF-ET) cycles using gonadotropin-releasing hormone antagonist (GnRH-ant) and gonadotropin-releasing hormone agonist (GnRH-a), as well as the risk factors for premature spontaneous ovulation. Methods The rates of premature spontaneous ovulation in a total of 10 612 cycles using GnRH-ant or GnRH-a were compared. Matched case-controlled study and binary logistic regression model were conducted to analyze the risk factors for premature spontaneous ovulation. Results The spontaneous ovulation rate in the whole for GnRH-a cycles was 0.15%(13/8 514), compared with a 1.62%(34/2 098) in GnRH-ant cycles (P<0.01). Further matched controlled study and regression analyze found out that higher basal FSH level was a predominant risk and prediction factor for spontaneous ovulation (OR=1.20, P=0.009). Conclusions In GnRH-ant cycles, spontaneous ovulation rate is about 10 times than which in GnRH-a cycles. Diminished ovarian function is a predominate risk factor for premature spontaneous ovulation.
