Associations between adipose tissue distribution and macro-vascular complications:A cross-sectional study in type 2 diabetic patients

Zhengyi Wang; Lin Ding; Yu XU; Xiaolin Huang; Ying Chen; Lin Lin; Ya Huang; Po Wang; Kui Peng; Jieli LU; Yuhong Chen; Min XU; Yufang BI; Meng Dai; Weiqing Wang

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Associations between adipose tissue distribution and macro-vascular complications:A cross-sectional study in type 2 diabetic patients

VernacularTitle:糖尿病患者脂肪分布与大血管并发症的相关性研究
Author: Zhengyi WANG ; Lin DING ; Yu XU ; Xiaolin HUANG ; Ying CHEN ; Lin LIN ; Ya HUANG ; Po WANG ; Kui PENG ; Jieli LU ; Yuhong CHEN ; Min XU ; Yufang BI ; Meng DAI ; Weiqing WANG
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Waist-to-hip ratio; Macro-vascular complications; Cardiovascular risks
From: Chinese Journal of Endocrinology and Metabolism 2016;32(5):361-369
CountryChina
Language:Chinese
Abstract: Objective This study aimed to investigate the associations between adipose tissue distribution and risks of macro-vascular complications in type 2 diabetic patients. Methods The study included T2DM patients either previously diagnosed by questionnaire or newly diagnosed with fasting plasma glucose(FPG)≥7. 0 mmol/L and/or 2 hour postprandial glucose ( 2h PG )≥11. 1 mmol/L from residents older than 40 years from Jiading Community, Shanghai, China(n=10 375). Each participant had gone through anthropometric measurements, blood tests, vascular function tests including carotid intima-media thickness ( CIMT ) , ankle-brachial index ( ABI ) , branchial-ankle pulse wave velocity( baPWV) as well as carotid plaques. Results WHR quartiles was significantly associated with high risks for ten-year cardiovascular disease risks [ ASCVD high risk: OR:1. 17 ( 1. 05-1. 31 );Framingham high risk:1. 13(1. 00-1. 29)]. However, WHR has no significant relations with risks of increased carotid intima-media thickness( CIMT) , abnormal ankle-brachial index( ABI) , increased brachial ankle pulse wave velocity( baPWV) or carotid plaques. Conclusions In type 2 diabetic patients, abdominal adipose tissue has an independent role in high risk for ten-year cardiovascular diseases. However it has no relations with other vascular functions including increased CIMT, abnormal ABI, increased baPWV, or carotid plaque.