The efficacy of trans-cranial magnetic stimulation for relieving post-stroke depression：A meta-analysis
10.3760/cma.j.issn.0254-1424.2016.05.018
- VernacularTitle:重复经颅磁刺激治疗脑卒中后抑郁症效果的Meta分析
- Author:
Yu JIN
;
Guoqiang XING
;
Zhiwei GUO
;
Qing TANG
;
Qiwen MU
- Publication Type:Journal Article
- Keywords:
Transcranial magnetic stimulation;
Stroke;
Depression
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2016;38(5):384-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effectiveness of repeated trans-cranial magnetic stimulation ( rTMS) in relieving post-stroke depression ( PSD). Methods PubMed, Embase, the Cochrane library, Web of Science, CNKI, WANFANG, and VIP were searched for reports of randomized, controlled trials of rTMS treatment of PSD published before June 2015. Crude standardized mean differences ( SMDs) and odds ratios with 95% confidence in-tervals ( CIs) were calculated for depression intensity and effectiveness rate after treatment using random or fixed effects models. Results Twenty-four studies involving 856 rTMS-treated patients and 802 control patients were in-cluded in the meta-analysis. The results showed that compared with the control group, PSD patients showed significant reductions in depression after rTMS treatment ( SMD=-1.36;95% CI-1.6 to-1.12;P≤0.05) . The total effective-ness rate in the treated group was 85% with a reduction in NIHSS score ( SMD=-0.82;95% CI-1.2 to-0.44;P≤0.05) . Subgroup analysis showed that neither the frequency of rTMS stimulation, the site stimulated, nor time after stroke had a significant influence on the effectiveness of rTMS. Additionally, a few studies reported adverse reactions after rTMS. Conclusion rTMS appears to be a safe and effective therapy for PSD. Further well-controlled trials may elucidate the mechanism underlying the placebo effects of the sham rTMS observed among PSD patients.
