Research progress of infectious mononucleosis

VernacularTitle:传染性单核细胞增多症研究进展
Author: Jia YU ; Lihong REN
Publication Type:Journal Article
Keywords: Infectious mononucleosis; Herpesvirus 4,human; Review
From: Chinese Journal of Postgraduates of Medicine 2016;39(5):475-478
CountryChina
Language:Chinese
Abstract: Infectious mononucleosis(IM) was one of the clinical common diseases, caused by epstein-barr virus infection in more than 90%patients. Changes of the surface antigen of the B cells with EB virus infection caused strong immune response of T lymphocytes, besides, helper T lymphocyte, dendritic cells, NK cells also played an important role in the pathogenesis of IM. The incidence of IM was not only closely related with social environment in childhood, but also closely with the number of siblings, birth order, and sunshine factor. In addition to the typical clinical manifestations, IM also can cause a variety of complications, such as spleen rupture and necrotizing mediastinitis , and could be life-threatening. Auxiliary examination means such as state of peripheral blood lymphocyte apoptosis, plasma proteomics, cerebrospinal fluid analysis, load test of EB virus can help to diagnose. Application of antiviral drugs was wider, but hormone was still controversial. Vaccine research progress had been slow, but there were vaccines for human test, which will provide effective measures for the prevention of IM.