Role of endoplasmic reticulum stress in diabetic atherosclerosis

VernacularTitle:内质网应激与糖尿病动脉粥样硬化研究进展
Author: Xueqi HOU ; Cong LIU ; Ling LI
Publication Type:Journal Article
Keywords: Endoplasmic reticulum stress; Unfolded protein response; Glucosamine; Insulin resistance
From: Chinese Journal of Postgraduates of Medicine 2016;39(5):472-475
CountryChina
Language:Chinese
Abstract: The diabetic patients died of cardiovascular disease mainly. However, the molecular and cellular mechanisms of diabetes complicated with atherosclerosis were still unclear. Endoplasmic reticulum (ER) stress may play a vital intermediate role in the progression of diabetic atherosclerosis. Both of diabetic hyperglycemia induced hexosamine pathway and diabetes induced macrophage insulin resistance can lead to ER stress. The unfolded protein response (UPR) produced by ER stress can be observed throughout the whole development course of atherosclerosis. In addition, ER stress also induced lipid deposition, cell apoptosis and inflammatory response, all of which was important for the progression of atherosclerosis. Though ER stress may be key for diabetes induced atherosclerosis, which pathway played the central role and the interaction between cytokines still need to be investigated. So that we could provide individual therapeutic scheme for treatment as well as prevention of diabetic complication.