Transmembrane Adaptor Proteins Positively Regulating the Activation of Lymphocytes.
- Author:
Inyoung PARK
1
;
Yungdae YUN
Author Information
- Publication Type:Review
- Keywords: TRAP (transmembrane adaptor protein); LAT (Linker for activation of T cells); LIME (Lck-interacting transmembrane adaptor protein); lymphocyte
- MeSH: Calcium Compounds; Lymphocyte Activation; Lymphocytes; Membranes; Oxides; Proteins
- From:Immune Network 2009;9(2):53-57
- CountryRepublic of Korea
- Language:English
- Abstract: Engagement of the immunoreceptors initiates signaling cascades resulting in lymphocyte activation and differentiation to effector cells, which are essential for the elimination of pathogens from the body. For the transduction of these immunoreceptor-mediated signals, several linker proteins termed transmembrane adaptor proteins (TRAPs) were shown to be required. TRAPs serve as platforms for the assembly and membrane targeting of the specific signaling proteins. Among seven TRAPs identified so far, LAT and LIME were shown to act as a positive regulator in TCR-mediated signaling pathways. In this review, we will discuss the functions of LAT and LIME in modulating T cell development, activation and differentiation.
