Resistance profile ofSalmonella isolates in hospital across China：results from CHINET Antimicrobial Resistance Surveillance Program, 2005-2014
- VernacularTitle:2005-2014年CHINET沙门菌属细菌耐药性监测
- Author:
Yunmin XU
;
Yan DU
;
Bin SHAN
;
Chuanqing WANG
;
Jianchang XUE
;
Hong ZHANG
;
Chun WANG
;
Yingchun XU
;
Xiaojiang ZHANG
;
Ziyong SUN
;
Cui JIAN
;
Fu WANG
;
Demei ZHU
;
Qing YANG
;
Yuxing NI
;
Jingyong SUN
;
Zhidong HU
;
Jin LI
;
Chao ZHUO
;
Danhong SU
;
Zhaoxia ZHANG
;
Ping JI
;
Yunsong YU
;
Jie LIN
;
Lianhua WEI
;
Ling WU
;
Yuanhong XU
;
Jilu SHEN
;
Yunjian HU
;
Xiaoman AI
;
Yunzhuo CHU
;
Yi XIE
;
Mei KANG
;
Yanqiu HAN
;
Sufang GUO
;
Bei JIA
;
Wenxiang HUANG
- Publication Type:Journal Article
- Keywords: Salmonella; antimicrobial agent; multidrug-resistant; bacterial resistance surveillance
- From: Chinese Journal of Infection and Chemotherapy 2016;16(3):294-301
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the distribution and changing resistance proifle ofSalmonella isolates in hospitals across China during the period from January 2005 to December 2014.Methods Seventeen general hospitals and two children’s hospitals were involved in this program. Antimicrobial susceptibility testing was carried out by means of a unified protocol using Kirby-Bauer method or MIC determination. The results were analyzed according to CLSI 2014 breakpoints.Results The proportion ofSalmonella isolates increased with time from 0.2% in 2005 to 0.7% in 2014. A total of 3 478Salmonella strains were collected from 19 hospitals. The proportion ofSalmonella typhimurium andSalmonella enteritidis was 27.4% and 24.4%, respectively. During the 10-year period, theSalmonella strains showed highest resistance rate to ampicillin (33.3%-64.8%), but low resistance to cefoperazone-sulbactam (0-5.3%) and ciprofloxacin (2.4%-14.3%).S. typhimurium showed higher resistance rate thanS. typhi,S. paratyphi andS. enteritidis. About 76.8% and 50.5% ofS. typhimurium were resistant to ampicillin and trimethoprim-sulfamethoxazole. The average prevalence of multi-drug resistantSalmonellawas 3.9% in the ten-year period, the highest (7.5%) was in 2005, the lowest (1.5%) in 2013.Conclusions During the period from 2004 to 2015, majority of theSalmonella isolates in hospitals across China wasS. typhimurium andS. enteritidis. Ampicillin and trimethoprim-sulfamethoxazole are no longer appropriate for empirical treatment ofS. typhimurium infection due to high resistance rate.Salmonella isolates are relatively more susceptible to third-generation cephalosporins and quinolones. Ongoing monitoring is necessary to identify multi-drug resistant strains ofSalmonella.