Research progress on the relationship between cognitive impairment in diabetes and NF-kappaB and its re-lated factors

VernacularTitle:NF-κB 及其相关因子与糖尿病认知功能障碍关系的研究进展
Author: Yuping PAN ; Shude LI ; Yingying ZOU
Publication Type:Journal Article
Keywords: Cognitive impairment in diabetes; Hippocampus; Nuclear Factor-kappa B; Nitric oxide synthase; Matrix metallo proteinase-9; Tumor necrosis factors-α
From: Journal of Medical Postgraduates 2016;29(7):754-758
CountryChina
Language:Chinese
Abstract: Cognitive impairment in diabetes ( CID) is one of the complications of diabetes .The features of mild or moderate cognitive disorder and the decread abilities in memory and studying are the main symptoms of CID .But it′s mechanism is still un-known .NF-κB is the original signal activator , it can activate other signal pathway of cell dysfunction .With the influence of hyperglyce-mia and oxidative stress, the expression of NF-κB is enhanced, that leads to the changes of the expression of NOS , MMP-9, TNF-α, then, these changes lead to the apoptosis of hippocampus neuron cell .This review focuses on NF-κB in order to provide evidences in studying CID by reviewing the relationship between NF-κB and it′s relative factors of NOS, MMP-9, TNF-αand CID.