A review on suspected chronic obstructive pulmonary disease genes
10.16571/j.cnki.1008-8199.2016.07.020
- VernacularTitle:慢性阻塞性肺病易感基因相关研究进展
- Author:
Tingzheng FANG
;
Yunyou DUAN
;
Min OU
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Genetic susceptibility;
Single nucleotide polymorphism;
Genome-Wide Association Study
- From:
Journal of Medical Postgraduates
2016;29(7):764-769
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease is thought to arise from the interaction of environmental exposures and genet -ic susceptibility, and major research efforts are underwent to identify genetic determinants and single nucleotide polymorphisms (SNPs) of COPD susceptibility.The suspected COPD genes include tumor necrosis factor (TNF)-a, transforming growth factor-b1 (TGF-b1), SERPINA1, matrix metalloproteinase 9 (MMP-9), microsomal epoxide hydrolase (EPHX1) and superoxide dismutase 3 (SOD3).A lot of Genome-Wide Association Study in COPD have identified some novel genes influencing COPD , such as CHRNA3/5, IREB2, HHIP and FAM13A.This review detailedly describe the advances in this field .
