Progress of induced pluripotent stem cell technology in the research of Parkinson′s disease

VernacularTitle:诱导性多能干细胞技术在帕金森病研究中的进展
Author: Peipei REN ; Jinyu FAN ; Huigen FENG ; Juntang LIN
Publication Type:Journal Article
Keywords: Induced pluripotent stem cells; Parkinson′s disease; Cell transplantation; Cell model
From: Journal of Medical Postgraduates 2016;29(7):770-774
CountryChina
Language:Chinese
Abstract: [Abstract ] In recent years, induced pluripotent stem cells (iPSCs) technology has played an important role in basic and clini-cal application research of Parkinson′s disease ( PD) and acquired significant progress .The neural progenitor /stem cells or dopamine ( DA) neurons which were obtained through iPSCs technique and direct differentiation technique from somatic cells were used for the study of cell therapy in PD , and good results were achieved .The cell models of DA neurons were established from PD patients carrying LRRK2, PAKK2, PINK or SNCA mutations via iPSCs technology , and the mitochondrial function and morphology , oxidative stress,α-synuclein ( SNCA) accumulation , and other aspects were studied on the pathogenesis of PD .This article briefly reviews the latest pro-gress of iPSCs technology in transplantation for treatment of PD and the establishment of cell model of PD disease , and provides refer-ence for further research .