Functions of innate lymphoid cells in inflammatory bowel disease

VernacularTitle:固有淋巴细胞与炎症性肠病的研究进展
Author: Huangbo GONG ; Xiaojun YANG ; Jin ZHU ; Hao WEN
Publication Type:Journal Article
Keywords: Innate lymphoid cells; Phenotype; Cytokine; Inflammatory bowel disease
From: Journal of Medical Postgraduates 2016;29(7):775-779
CountryChina
Language:Chinese
Abstract: Innate lymphoid cell is a type of newly discovered innate immune cell , which can function as adaptive T cells . Based on the transcription factors and the expression of effector cytokines , innate lymphoid cells can be categorized into three sub-groups:ILC1, ILC2 and ILC3.The inflammatory factors these produced by ILC play an important role in the development of inflamma -tory bowel disease (IBD), but ILC3 can secrete IL-22, which promotes the restoration of intestinal epithelial cells .Exploring the func-tion of ILC has a great significance in the treatments of IBD .This article reviews their phenotype , function and also relationship with IBD.