Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria.
10.3858/emm.2009.41.4.028
- Author:
Jung Eun LEE
1
;
Hansoo PARK
;
Young Seok JU
;
Minhye KWAK
;
Jong Il KIM
;
Ha Young OH
;
Jeong Sun SEO
Author Information
1. Division of Nephrology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
albuminuria;
cardiovascular diseases;
DNA, mitochondrial;
mitochondria;
oxidative phosphorylation
- MeSH:
Adult;
Albuminuria/blood/*epidemiology/*genetics;
Cross-Sectional Studies;
DNA, Mitochondrial/blood/*genetics;
Female;
*Gene Dosage;
Humans;
Male;
Middle Aged;
Regression Analysis;
Young Adult
- From:Experimental & Molecular Medicine
2009;41(4):253-258
- CountryRepublic of Korea
- Language:English
-
Abstract:
It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondrial DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P = 0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P = 0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P = 0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.
