Reconsideration on therapeutic strategy of critical infection of children
10.3760/cma.j.issn.1673-4912.2016.06.008
- VernacularTitle:儿科重症感染治疗策略的再认识
- Author:
Xiaodong ZHU
- Publication Type:Journal Article
- Keywords:
Paediatrics;
Infection;
Antibiotics;
Microbiology;
Clinical pharmacy
- From:
Chinese Pediatric Emergency Medicine
2016;23(6):392-396
- CountryChina
- Language:Chinese
-
Abstract:
Serious infection,antibiotic resistance and uncompleted development of organ function are critical problems for pediatrician.The hitting hard and de-escalation are important strategies of antibiotics ap-plication for anti-infection therapy.The emphasis of early applying of broad spectrum antibiotics saved a lot pediatric critically ill patients.Meanwhile,problems gradually appeared such as the overuse of antibiotics,the start time of de-escalation therapy and the impact on the clinical prognosis of patients.Considering that pedi-atric related results of cliniac l research were absent,an anti-infce tion therapy which is guided by microbiolo-gical test and clinical pharmacy is actually needed in the treatment of critically ill patients.Appropriate antibi-otics are chosen based on pathogenic bacetri um detectni g,which avoied sth e overuse of broad spectrum antibi-otics and side effects following overuse of antibiotics.Pathological and physiological changes of critical child should also be considered completely.The pharmacokni etics/pharmacodynamics principle of antibiotics should be followed basing on blood medicinal concentration assay for rational usage of antibiotics.Finally, more randomized controlled trials and real world research trials would be needed for pediatric anti-infection therapy in the future.
