Mechanism of transforming growth factorβin patients with hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2016.06.019
- VernacularTitle:转化生长因子β信号通路在肝癌患者中的作用机制
- Author:
Tao ZHENG
;
Jiamei YANG
- Publication Type:Journal Article
- Keywords:
Transforming growth factor β;
Signaling pathway;
Hepatocellular carcinoma;
Epithelial to mesenchy-mal transition
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(6):425-428
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor β( TGF-β) plays an important role in regulating cell proliferation , differentiation and apoptosis , and also in the carcinogenesis .Unlike its tumor suppressor function in normal tissue , continuous activation of TGF-βsignaling pathway in inflammatory microenvironment and cancer tissue promotes the progression of hepatocellular carcino-ma ( HCC) .Loss of Smad4 and epithelial to mesenchymal tran-sition ( EMT ) may be the potential mechanisms how TGF-βtransforms from a tumor suppressor to a tumor promoter .Further studies on regulatory mechanism of TGF-βsignaling pathway are of great significance , which could provide new evidence for pre-venting and treating HCC .
