Inflammation characteristics of nonallergic rhinitis with eosinophilia syndrome
10.16571/j.cnki.1008-8199.2016.07.012
- VernacularTitle:非变应性鼻炎伴嗜酸性粒细胞增高征患者的炎症特征
- Author:
Zhiyi WANG
;
Minghai WU
;
Yong ZHANG
;
Wei CHEN
;
Minhui ZHU
;
Qiuping WANG
;
Hongliang ZHENG
- Publication Type:Journal Article
- Keywords:
Allergic rhinitis;
Nonallergic rhinitis with eosinophilia syndrome;
Nasal douche;
Induced sputum;
Nasal provo-cation test;
Bronchial provocation test;
Fractional exhaled nitric oxide
- From:
Journal of Medical Postgraduates
2016;29(7):727-730
- CountryChina
- Language:Chinese
-
Abstract:
Objective Nonallergic rhinitis with eosinophilia syndrome (NARES) is associated with such diseases as bronchial asthma , nasal polyps , and aspirin intolerance , but there is a lack of studies on its inflammatory conditions .The aim of this study is to describe the inflammation characteristics of NARES . Methods This study included 101 cases of allergic rhinitis ( AR) , 39 cases of NARES, and 162 adult controls .We analyzed the inflammation char-acteristics of the patients using skin prick test ( SPT) , nasal douche , fractional exhaled nitric oxide ( FeNO ) measurement , serum eosino-phil (EOS) counting, serum total IgE (tIgE) determination, induced sputum detection, and nasal and bronchial provocation tests . Results Compared with the controls , the NARES and AR groups showed significant increases in the positive rate of nasal provocation (32.1%vs 69.2%and 75.2%, P<0.05), positive rate of bronchial provocation (1.2%vs 10.3%and 14.9%, P<0.05), and FeNO level ([15.70 ±5.20] ppb vs [37.25 ±22.95] and [39.00 ±24.29] ppb, P<0.05), as well as in the serum EOS and tIgE levels, EOS count, and ratio of EOS in the induced sputum (P<0.05).However, the level of serum tIgE was significantly lower in the NARES than in the AR group (53.3 [23.3-186.0] kU/L vs 197.0 [62.6-391.0] kU/L, P<0.05). Conclusion NARES is a syndrome with nasal, lower airway, and systematic inflammation, similar to AR in inflammatory intensity.Therefore, for patients with NARES, attention should be paid not only to upper airway but also to lower airway and systemic inflammation .
