Safety and short-term effect of irreversible electroporation ablation of hepatic neoplasms
10.3760/cma.j.issn.1005-1201.2016.07.010
- VernacularTitle:肝恶性肿瘤不可逆电穿孔消融的安全性和近期疗效
- Author:
Lizhi NIU
;
Guifeng LIU
;
Jianying ZENG
;
Yi CAI
;
Xiaofeng KONG
;
Bing LIANG
;
Liang ZHOU
;
Gang FANG
;
Shuying LI
;
Zhonghai LI
;
Rongrong LI
;
Kecheng XU
- Publication Type:Journal Article
- Keywords:
Ablation techniques;
Liver neoplasms
- From:
Chinese Journal of Radiology
2016;50(7):526-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the safety and short?term efficacy of irreversible electroporation (IRE)ablation which is a novel ablation technology in unresectable hepatic neoplasms. Methods Patients with pathologically diagnosed as liver cancer or liver metastases were prospectively enrolled. The patients were not suitable for surgery with PS score ≤ 2. Exclusion criteria included who was not tolerate general anesthesia, severe liver and kidney dysfunction, and with cardiac pacemaker. A total of 16 patients were included in this study. There was 12 males and 4 females, aged 40 to 86 years with mean age (60 ± 10)y. Ultrasound and CT guided percutaneous IRE ablation was performed. Perioperative hemodynamic changes were reviewed. Liver and kindey function before and 7 d after ablation was compare by t test. The adverse reactions within 30 d after ablation treatment were recorded. CT and MR scans within 1 month were performed and the 30 d curative effect was evaluated by the modified RECIST criteria. Results All patients received IRE treatment successfully, and some patients experienced adverse reactions within 30 days after ablation, including abdominal pain in 7 cases, peritoneal effusion in 5 cases, hydrothorax in 4 cases, fever in 3 cases, cough, nausea and vomiting in 2 cases, biliary tract infection and thrombocytopenia in 1 case. After symptomatic treatment, these symptoms were improved. Severe complications, such as massive haemorrhage and bile leakage didn't occur. At 30 days after ablation, the curative effects were evaluated. Complete response (CR) was achieved in 1 patient , partial response (PR) was achieved in 12 patients, stable disease (SD) was in 2 patients , and progressive disease(PD) was 1 patients . The tumor relief rate (complete response+partial response) was 81.3%. Conclusions IRE ablation in the treatment of unresectable hepatic malignant tumor could have many advantages, including high safety, mild adverse reactions, and short?term efficacy. However, its long?term effect still need further observation.
