Diagnostic Value of Serum Pepsinogen,Gastrin-17 and Helicobacter pylori Antibody for Atrophic Gastritis and Gastric Cancer
10.3969/j.issn.1008-7125.2016.06.014
- VernacularTitle:血清胃蛋白酶原、胃泌素-17、幽门螺杆菌抗体检测对萎缩性胃炎和胃癌的诊断价值
- Author:
Jianye ZHAO
;
Chunping ZHU
;
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
Pepsinogens;
Gastrins;
Gastritis,Atrophic;
Stomach Neoplasms;
Helicobacter pylori;
Diagnosis
- From:
Chinese Journal of Gastroenterology
2016;21(6):376-379
- CountryChina
- Language:Chinese
-
Abstract:
Numerous studies showed that changes in serum pepsinogen( PG)and gastrin-17( G-17)levels can reflect histological condition of gastric mucosa,that can be served as serological biopsy of gastric fundic glandular mucosa. The decrease of serum PGⅠ level and PGⅠ/ PGⅡ ratio(PGR)as well as increase of G-17 denotes a high risk of gastric cancer. Helicobacter pylori(Hp)infection can cause chronic active gastritis,and the progress of inflammation can lead to atrophy and intestinal metaplasia of mucosa. This article reviewed the diagnostic value of serum PG,G-17 and Hp antibody for atrophic gastritis and gastric cancer.
