Role of Aquaporins in Modulating Diarrhea-predominant Irritable Bowel Syndrome
10.3969/j.issn.1008-7125.2016.06.015
- VernacularTitle:水通道蛋白调控腹泻型肠易激综合征的研究进展
- Author:
Linying JIN
;
Shuo ZHANG
- Publication Type:Journal Article
- Keywords:
Irritable Bowel Syndrome;
Diarrhea;
Aquaporins;
Water Metabolism;
Neuromodulation
- From:
Chinese Journal of Gastroenterology
2016;21(6):380-382
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporins,known as a family of water channel proteins,are crucial factors involved in colonic transmembrane water transport and play important roles in maintaining the homeostasis of internal and external environment of intestinal cells and modulating enteric nerve functions. Diarrhea-predominant irritable bowel syndrome( IBS-D)is a commonly seen gastrointestinal functional disorder in clinical practice. Recently,there are more and more researches focusing on the roles of aquaporins in IBS-D,however,mechanisms of its protective or damaging effects on IBS-D are still not clear. In this review article,the progress of research on the modulatory effect of aquaporins in IBS-D was summarized.
