Differentiation of pancreas carcinoma from healthy pancreas using diffusion-weighted MR imaging:comparison of apparent diffusion coefficient and intravoxel incoherent motion-derived parameters
10.3760/cma.j.issn.1005-1201.2016.06.006
- VernacularTitle:MR扩散加权成像单指数模型及体素内不相干运动模型参数诊断胰腺癌的价值
- Author:
Wei HE
;
Yan ZHOU
;
Jianyu LIU
;
Zhenyu ZHOU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Magnetic resonance imaging;
Comparative study
- From:
Chinese Journal of Radiology
2016;50(6):427-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic performance of multi ? b value DWI to differentiate pancreatic adenocarcinoma from healthy pancreas using the apparent diffusion coefficient (ADC) and parameters derived from the intravoxel incoherent motion (IVIM) theory. Methods Forty?eight patients with histopathologically proven pancreatic adenocarcinoma and fifty patients with healthy pancreas were examined at 3.0 Tesla using a single?shot echo?planar imaging DWI pulse sequence. Eight b?values ranging from 0 to 1 000 s/mm2 were used. ADC, diffusion coefficient (D), perfusion?related diffusion (D*) and perfusion fraction (f) were compared between pancreatic adenocarcinoma and healthy pancreas, t test or Mann?Whitney U test was used to compare the MRI parameters, ROC was used to evaluate the diagnostic efficiency. Results In comparison to healthy pancreatic tissue, a significant reduction of the ADC, D*and f was found in pancreatic adenocarcinoma [healthy pancreatic tissue:(1.68±0.31)×10-3mm2/s, 27.10×10-3mm2/s, (36.92±12.47)%;pancreatic adenocarcinoma:(1.51±0.37)×10-3mm2/s, 13.90×10-3mm2/s, (30.06±19.84)%] (P<0.05). No significant difference in the diffusion coefficient D was observed between the two groups (1.06× 10-3 and 1.26 × 10-3mm2/s; P>0.05). In the ROC?analyses, the area under curve for D* was the largest (0.727), followed by f and ADC in order (0.680 and 0.669). Conclusion Using the IVIM DWI approach, the D*, f and ADC value are useful for differentiating pancreatic adenocarcinoma from healthy pancreatic tissue.
