Surgical treatment of intrahepatic cholangiocarcinoma：a retrospective study of 104 cases
10.3760/cma.j.issn.1007-8118.2016.06.008
- VernacularTitle:肝内胆管细胞癌104例外科治疗的回顾
- Publication Type:Journal Article
- Keywords:
Intrahepatic cholangiocarcinoma;
Surgical treatment;
Lymph node dissection;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(6):382-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathological features , surgical techniques and prognosis of patients with intrahepatic cholangiocarcinoma ( ICC) .Methods The data of 104 patients with ICC trea-ted from Jan.2008 to Dec.2013 at the Tianjin Medical University Cancer Hospital were retrospectively re -viewed.The overall survival (OS) rate and the independent risk factors related to survival were analyzed . Rseult s The 1-, 2-, and 3-year OS rates of these patients were 72.1%, 56.1%and 43.7%, respective-ly, and the median survival was 34 months.The 1-, 2-, and 3-year OS rates in the hepatic hilum lymphade-nectomy group were 42.9%, 28.6%and 28.6%, which were significantly lower than the non-lymphadenec-tomy group (78.9%, 62.5%and 47.8%).The 1-, 2-, and 3-year OS rates in the extended hepatic hilum lymphadenectomy group(75.0%, 66.7% and 33.3 %) was not significantly different from the other two groups.Univariate analysis showed that age , gender, AJCC stage, differentiation, ferritin (Fer), CA19-9, CEA, lymph node metastasis and lymph node dissection were prognostic factors of long -term survival for pa-tients with ICC (P<0.05).Multivariate analysis revealed that age , AJCC stage, differentiation, Fer, and lymph node metastasis were independent risk factors of survival ( P<0.05 ) .Conclusions Patients with ICC would not benefit from lymphadenectomy if no lymph node involvement was present .Systematic lymph-adenectomy improved the outcomes of patients with lymph node metastasis .Age, AJCC stage, differentia-tion, Fer and lymph node metastasis were independent risk factors of survival .
