Formula Optimization of Regorafenib Solid Dispersion by Orthogonal Test
- VernacularTitle:正交试验优选瑞戈非尼固体分散体的处方工艺
- Author:
Zhengping LIU
;
Mingsen WANG
;
Dawei LI
;
Huijuan SUN
;
Lili WANG
;
Xinfang ZHANG
;
Jianqiang ZHANG
- Publication Type:Journal Article
- Keywords:
Regorafenib;
Solid dispersion;
Orthogonal test;
Dissolution
- From:
China Pharmacist
2016;19(6):1059-1063
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the formula of regorafenib solid dispersion .Methods: On the basis of preliminary studies on the carrier and drug/carrier ratio, an orthogonal test was used to study the formula of regorafenib solid dispersion .The orthogonal table of L9 (34 ) was designed to study the drug/carrier ratio, ultrasound time and bath temperature .Results: Regorafenib solid dispersion was prepared by a solvent method with polyvinylpyrrolidone K 30 as the carrier.The drug/carrier ratio was 1 ∶7, the ultrasound time was 4min, and the bath temperature was 30℃.Regorafenib solid dispersion showed good stability confirmed by differential scanning calorimetry and X-ray diffraction .The dissolution in 30 min reached above 90 %.Conclusion: The preparation process is stable and reproducible , which can be used to prepare regorafenib solid dispersion .
