Clinical effect of ganglion glycosides in the treatment of neonatal hypoxic ischemic encephalopathy
10.3760/cma.j.issn.1008-6706.2016.11.033
- VernacularTitle:神经节苷脂治疗新生儿缺血缺氧性脑病临床效果分析
- Author:
Guozhong ZOU
;
Jinhua YE
- Publication Type:Journal Article
- Keywords:
Hypoxic-ischemic encephalopathy;
Newborns;
Ganglioside
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(11):1729-1732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the brain CT index,neurological scores and efficacy of ganglion glycosides in treating neonatal hypoxic ischemic encephalopathy (HIE).Methods Seventy-two patients with HIE hospitalized in our hospital were randomly selected as the research objects during November 2012 to November 2014.The patients were divided into observation group(36 cases) and control group(36 cases) according to the time of admission.The patients in control group were treated with routine treatment.The observation group was treated with ganglion glycosides on the basis of the conventional treatment.After two weeks treatment,the brain CT index,neurological scores and efficacy were observed.Results After treatnent,with CT examination the patients in the observation group showed mild HIE in 33 cases,which was significantly more than the control group,and severe HIE in 3 cases,which was significantly less than the control group.There were significant differences between the two groups (x2 =7.005 4,11.840 2,all P ＜ 0.05).The recovery time of consciousness,reflex recovery time,recovery time of muscle tension of the observation group were (5.08 ± 1.02) d,(6.74 ± 1.53) d,(7.31 ± 1.69) d,which were shorter than the control group,and the differences between the two groups were statistically significant (t =13.002 7,5.354 6,6.224 0,all P ＜ 0.05).After treatment,there were no deaths in the two groups,the observation group of 1 patient with ataxia,2 cases of mental retardation,epilepsy in 1 case and 0 case of cerebral palsy,which were less than the control group,there were significant differences between the two groups (x2 =7.407 4,P ＜ 0.05).Conclusion For the newborn with HIE after treating with ganglion glycosides,the CT index and neurological score showed obvious improvement,and the treatment effect is good,thus it is worth popularizing.
