The efficacy of milrinone micropump in treatment of chronic heart failure and the influence to the level of amino-terminal B-type natriuretic peptide precursor in serum
10.3760/cma.j.issn.1008-6706.2016.11.031
- VernacularTitle:米力农治疗慢性心力衰竭的疗效及其对血清氨基末端B型钠尿肽前体水平的影响
- Author:
Biao DU
;
Houtian XU
;
Limin CHEN
- Publication Type:Journal Article
- Keywords:
Heart failure;
Milrinone;
Natriuretic peptide,type B
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(11):1722-1725
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of milrinone micropump in treatment of chronic heart failure(CHF),and the influence to the level of amino-terminal B-type natriuretic peptide precursor(NT-proBNP) in serum.Methods 120 cases with CHF were selected,they were randomly divided into the observation group and the control group according to a random number table.The patients of the control group were treated with standardized anti -conventional treatment of heart failure according to their heart function,the patients of the observation group were given milrinone micropump on the basis of the standardized anti-conventional treatment of heart failure.The efficacy of clinical conditions 1 week after treatment and NT-proBNP levels in serum before and after treatment were compared between two groups.Results The clinical efficacy of the observation group was 95.00％,which was higher than 76.67％ of the control group,the difference was statistically significant(x2 =8.67,P ＜ 0.05).The serum level of NT-proBNP of the observation group was (38.9 ± 9.2) ng/L,which was significantly lower than (86.3 ± 32.4) ng/L of the control group,the difference was statistically significant (t =9.86,P ＜ 0.05).Conclusion Milrinone micro pump used in the treatment of CHF can significantly improve the clinical efficacy,and lower the serum level of NT-proBNP,improve heart function,it is safe and reliable and worth to application in the clinical.
