Effects of aerosol tiotropium and salmeterol/fluticasone propionate aerosol on lung function in patients with COPD and related indicators
10.3760/cma.j.issn.1008-6706.2016.11.023
- VernacularTitle:噻托溴铵气雾剂联合沙美特罗替卡松气雾剂对慢性阻塞性肺疾病患者肺功能及相关指标的影响
- Author:
Xiangwen XU
;
Nianzhi ZHANG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Pulmonary function;
Tiotropium bromide aerosol;
Salmeterol/fluticasone aerosol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(11):1692-1695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects of salmeterol/fluticasone propionate aerosols fluticasone propionate and salmeterol joint tiotropium aerosol on pulmonary function and exercise tolerance in patients with chronic obstructive pulmonary disease (COPD),and to provide a theoretical basis for clinical treatment.Methods 119 COPD patients were selected in this study.They were randomly divided into 65 cases of seretide group and 54 cases of combined treatment group.Before treatment,three months after treatment and six months after treatment,the pulmonary function and 6MWD were measured in all patients.Results After 3 months,6 months of treatment,the FEV1,FEV1/FVC,FVC,6MWD of the combined treatment group had significant differences compared with before treatment (ta =-5.89,tb =-6.88,te =-8.46,tf =-8.86,ti =-10.74,tj =-8.52,tm =-9.37,tn =-13.04,all P ＜0.05).After 3 months,6 months of treatment,the FEV1,FEV1/FVC,FVC,6MWD in the control group had significant differences compared with before treatment (tc =-4.29,td =-7.19,tg =-6.16,th =-11.40,tk =-11.69,tl =-7.43,to =-11.71,tp =-10.53,all P ＜ 0.05).After 3 months of treatment,the differences of FEV1,FEV1/FVC,FVC between two groups were significant (tv =2.69,tq =6.74,tr =2.91,all P ＜ 0.05).In the control group,theFEV1,FEV1/FVC,FVC after 6 months of treatment had significant differences compared with after 3 months of treatment(ts =-2.50,tt =-9.46,tu =-1.65,all P ＜ 0.05).Conclusion Seretide and tiotropium aerosol aerosol can better improve lung function in patients with COPD and exercise tolerance,but the result of using two drugs to improve the patients'lung function was significantly better than seretide alone.
