Analysis of 17 175 cases with results of physical examination crowd EB virus antibody positive
10.3760/cma.j.issn.1008-6706.2016.11.013
- VernacularTitle:17175例体检人群中EB病毒抗体阳性结果分析
- Author:
Shanchang CHEN
;
Jiaen WU
;
Dong CHEN
;
Jingyun HU
;
Ling PENG
;
Xiaojuan ZHANG
- Publication Type:Journal Article
- Keywords:
Medical groups;
EB antibody detection;
Nasopharyngeal carcinoma;
Biopsy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(11):1653-1655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between nasopharyngeal carcinoma and positive IgA antibodies of EB virus nuclear antigen 1 (NA),EB virus capsular antigen (VCA) and EB virus Zta protein.Methods The serum EB virus VCA-IgA,NA1-IgA and Zta-IgA antibody in 17 175 cases were detected by ELISA.782 cases of EB virus antibody-positive subjects were further given nasopharyngeal CT imaging,electronic nasopharyngoscopy.Finally confirmed by biopsy and immunohistochemistry.Comparison of serology results EB antibody-positive individual,while the two antibody-positive and antibody while three positive nasopharyngeal carcinoma detection rate,combined with evaluation of EB virus antibody detection in nasopharyngeal carcinoma screening value of high-risk groups.Results 17 175 cases of medical groups,the EB virus antibodies were detected in 782 cases,with the most positive individual,accounting for 535 cases (68.41％),nasopharyngeal cancer diagnosed in 15 cases (2.80％);two antibody positive while 213 cases (27.24 ％),diagnosed 49 cases of nasopharyngeal carcinoma (23.00％);least three antibody positive while only 34 cases (4.35％),nasopharyngeal cancer diagnosed 18 patients (52.94％);by physical examination,in 16,393 cases of EB virus antibody negative population by nasopharyngoscopy and throat CT and other medical examination,the final diagnosis of nasopharyngeal carcinoma in 6 cases (0.04％).Conclusion Three EB virus antibody combined detection greatly improves the rate of nasopharyngeal cancer diagnosis;we must also do other physical examination to prevent EB virus antibody-negative nasopharyngeal crowd missed.
