Research progress of Wnt/β-catenin signaling pathway in tumor drug resistance
10.3760/cma.j.issn.1673-422X.2016.06.015
- VernacularTitle:Wnt/β-catenin信号通路在肿瘤耐药中的研究进展
- Author:
Zhigang YI
;
Kaisheng ZHOU
;
Yanchuan PU
;
Xingwen WANG
;
Shuanke WANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Drug tolerance;
Wnt/β-catenin signaling pathway
- From:
Journal of International Oncology
2016;43(6):455-457
- CountryChina
- Language:Chinese
-
Abstract:
Wnt/β-catenin signaling pathway participates in cancer cell proliferation,invasion and metastasis and effectively induces drug resistance.It is also the key signal to mediate cancer carcinogenesis.Recent studies in vitro indicate that disturbance of Wnt/β-catenin signaling pathway can increase the sensitivity of the cancer cells to chemotherapeutic drugs.In-depth researches and analysis of tumor drug resistance induced by Wnt/β-catenin will provide potential targets and possible therapeutic means for the treatment of tumors.
