Predictive biomarkers in tumor treatment by blocking PD-1/PD-L1 pathway
10.3760/cma.j.issn.1673-422X.2016.06.014
- VernacularTitle:生物标志物在阻断PD-1/PD-L1通路治疗肿瘤中的预测性作用
- Author:
Jinyuan CUI
;
Kaixiong TAO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Therapy;
Biological markers;
PD-1/PD-L1 pathway
- From:
Journal of International Oncology
2016;43(6):452-454
- CountryChina
- Language:Chinese
-
Abstract:
Identifying biomarkers predicting clinical response to treatment of PD-1/PD-L1 pathway blockade can guide patient selection and therapeutic individualization.Some researches have shown that patients with cancer will acquire better clinical effects by blocking PD-1/PD-L1 pathway whose characteristics include higher pretreatment expression of PD-L1 by tumor cells or tumor infiltrating immune cells,the massive infiltration of intratumoral CD8 + T cells,the high mutation frequency of tumor cell gene.These biomarkers are expected to become indicators which can select patients.
