Progression of secreted frizzled-related protein family in cancer
10.3760/cma.j.issn.1673-422X.2016.06.013
- VernacularTitle:分泌型卷曲相关蛋白家族在肿瘤中的研究进展
- Author:
Lihong LI
;
Zhongtian BAI
;
Jinjing HU
;
Wence ZHOU
- Publication Type:Journal Article
- Keywords:
Signal transduction;
Targeted gene repair;
Neoplasms;
Secreted frizzled-related protein
- From:
Journal of International Oncology
2016;43(6):448-451
- CountryChina
- Language:Chinese
-
Abstract:
Secreted frizzled-related protein (SFRP) can inhibit the expression of Wnt signaling pathway through Frizzled protein.The silencing of SFRP gene promoter methylation is associated with the occurrence and metastasis of many cancers such as colorectal cancer,gastric cancer,liver carcinoma,lung cancer and ovarian cancer.Several studies have found that SFRP gene has latent clinical value,which is expected to become the novel target for the gene diagnosis and treatment of cancer.
