Expression and role of microRNA-375 in cancer

VernacularTitle:微小RNA-375在肿瘤中的表达及作用
Author: Yang LIU ; Nan CHEN ; Jinqiao PANG ; Chengxiu XIONG ; Gaofeng LI
Publication Type:Journal Article
Keywords: MicroRNAs; Neoplasms
From: Journal of International Oncology 2016;43(6):442-444
CountryChina
Language:Chinese
Abstract: MicroRNA-375 (miR-375) is closely related to the development of cancer,such as liver cancer,gastric cancer,pancreatic cancer,endometrial cancer,esophageal cancer,non-small cell lung cancer,etc.The mainly tumor pathogenesis related miR-375 includes that miR-375 is combined with specific target genes,can degrade mRNA or inhibit protein translation in the transcriptional level,and plays antitumor effect of inhibition of cell proliferation,promoting cell apoptosis and inhibiting the invasion and metastasis.miR-375 is expected to be a new target for cancer therapy,which may become an important biomarker for the diagnosis,treatment and prognosis of cancer.