Semaphorin familily and glioma
10.3760/cma.j.issn.1673-422X.2016.04.016
- VernacularTitle:Semaphorin家族与胶质瘤
- Author:
Haidong ZHANG
;
Wei ZHANG
;
Hui WANG
;
Guangting ZHU
- Publication Type:Journal Article
- Keywords:
Semaphorins;
Glioma;
Cell movement;
Neoplasm invasiveness
- From:
Journal of International Oncology
2016;43(4):299-301
- CountryChina
- Language:Chinese
-
Abstract:
Semaphorins act as axon guidance molecules,which were either secretory or binding to the cell surface.All its family members contain a Sema structure,which is composed of about 500 amino acid residues and is essential for its biological activity.Functionally,they play different roles in tumors,such as oncogenes or tumor suppressor genes,and their abnormal expressions are related to the proliferation,migration and invasion of glioma cells.Semaphorins may be the therapeutic targets for the clinical treatment of glioma.
