3-Phosphoinositide-dependent protein kinase-1 in tumor genesis, development and treatment
10.3760/cma.j.issn.1673-422X.2016.04.012
- VernacularTitle:3-磷酸肌醇依赖性蛋白激酶1在肿瘤发生发展及治疗中的作用
- Author:
Tiantian LIU
;
Jingwang BI
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Signal transduction;
3-Phosphoinositide dependent kinase-1
- From:
Journal of International Oncology
2016;43(4):285-288
- CountryChina
- Language:Chinese
-
Abstract:
3-phosphoinositide dependent kinase-1 (PDK1) has been shown to be a critical regulator of the PI3K-Akt pathway.PDK1 can activate Akt and participates in the activation of PI3K-Akt signaling pathway to promote tumor development,invasion and metastasis.At present,it has been found that PDK1 is highly expressed in head and neck cancer,multiple myeloma,pancreatic cancer,esophageal cancer,colon cancer and other malignant tumors.Thereby inhibiting PDK1 overexpression may provide a new breakthrough for the treatment of malignant tumor.At present,many kinds of PDK1 inhibitors have been put into production,which plays an important role in tumor therapy.
