Research progression about the HMGN protein in tumor
10.3760/cma.j.issn.1673-422X.2016.04.010
- VernacularTitle:高迁移率族蛋白N在肿瘤中的研究进展
- Author:
Beili LIU
;
Yixin WAN
- Publication Type:Journal Article
- Keywords:
HMGN proteins;
Neoplasms;
Cell cycle;
Alarmins
- From:
Journal of International Oncology
2016;43(4):278-281
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group N (HMGN),one member of the high mobility group superfamily,is expressed ubiquitously in living cells.HMGN can bind directly to nucleosomes and modulate the structure of the chromatin fiber,which affect the cellular transcription profile and cellular differentiation and the ability to repair damaged DNA.The occurence of tumor is closely related to the abnormal transcription caused by accumulation of mutations.Abnormal transcription can prompt the tumor cells to escape from the tight regulation of cell cycle progression.Studies show that HMGN plays an important role in cancer progression by involving in the regulation of tumor cell cycle and affecting the biological behavior of tumor cells.
