Mechanisms of FOXM1 in carcinogenesis and the progression of the anti-FOXM1 target drugs
10.3760/cma.j.issn.1673-422X.2016.04.009
- VernacularTitle:FOXM1致癌机制及其分子靶向药物
- Author:
Chuan TIAN
;
Qi LI
- Publication Type:Journal Article
- Keywords:
Forkhead transcription factors;
Neoplasms;
Antitumor drugs
- From:
Journal of International Oncology
2016;43(4):274-277
- CountryChina
- Language:Chinese
-
Abstract:
Forkhead box M1 (FOXM1),one member of the Forkhead family,plays an important role in tumor development,invasion,metastasis and angiogenesis by regulating the expression of tumor related genes.Moreover,The specific mechanism of FOXM1 is not fully understood in the development of tumors.Currently,the study of anticancer drugs targeting FOXM1 is in the initial stage.Exploring the mechanism of FOXM1 in carcinogenesis and the development of drugs targeting FOXM1 and its downstream signaling pathways have broad clinical application prospects.
