Research progress of carboxyl peptide fragment of clostridium perfringens enterotoxin in the treatment of tumors
10.3760/cma.j.issn.1006-9801.2016.05.020
- VernacularTitle:产气荚膜梭菌肠毒素羧基端多肽片段在肿瘤治疗中的研究进展
- Author:
Hong CHEN
- Publication Type:Journal Article
- Keywords:
Clostridium perfringens enterotoxin;
Carboxyl peptide fragment of clostridium perfringens enterotoxin;
Claudin protein;
Neoplasms;
Therapy
- From:
Cancer Research and Clinic
2016;28(5):353-356
- CountryChina
- Language:Chinese
-
Abstract:
There are approximately 85 ％ of malignant tumors derived from epithelial cells,and a therapeutic method of epithelial cells has become the focus of cancer treatment.Claudin-3 and Claudin-4 as important components of the tight junction structure are abundantly expressed in malignant tumors,and the clostridium perfringens enterotoxin (CPE) as Claudin-3 and Claudin-4 specific binding ligand has important significances in the treatment of tumors.However,because of the large intestinal toxicity,clinical application of CPE has been limited greatly.Carboxyl peptide fragment of CPE (C-CPE) is a specific binding domain of CPE,which has specificity without intestinal toxicity.This review will present some advances of C-CPE in cancer therapy.
