Relationship between p16, p27 proteins and clinicopathological characteristics of breast cancer and their prognostic value
10.3760/cma.j.issn.1006-9801.2016.05.007
- VernacularTitle:p16、p27蛋白与乳腺癌临床病理特征的关系及预后价值
- Author:
Jinping XU
;
Weida SHEN
;
Yingzi ZHOU
;
Yun ZHANG
;
Xuejun ZHAO
;
Bing LI
;
Xiaojie WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Immunohistochemistry;
p16;
p27;
Prognosis
- From:
Cancer Research and Clinic
2016;28(5):315-317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between p16,p27 proteins and clinicopathological characteristics of breast cancer and their prognostic value.Methods p16 protein and p27 protein were detected by two step immunohistochemical method in 93 tissues of breast cancer.Results The positive rates of p16 protein and p27 protein were 46.2 ％ (43/93) and 54.8 ％ (51/93).The positive rate of p16 protein in different tumor location (left/right),the maximal diameter and histological type had no statistically significant difference (all P ＞ 0.05),but in the different age groups and axillary lymph node metastasis,the differences were statistically significant (both P ＜ 0.05).The positive rate of p27 protein in different age groups,tumor location (left/right) and the maximal diameter had no significant difference (all P ＞ 0.05),but was correlated with the infiltration and axillary lymph node metastasis (both P ＜ 0.05).Conclusions The negative expression of p16 and p27 is significantly related with the biological behaviors of breast cancer.Detection of both p16 protein and p27 protein may play an important role in predicting the prognosis of breast cancer.
