Cox regression analysis of prognostic factors of operative patients with colorectal cancer with time covariates

VernacularTitle:结直肠癌手术患者预后影响因素的时协变量Cox回归分析
Author: Man HE ; Ruixin SUO ; Yulan QIU
Publication Type:Journal Article
Keywords: Colorectal neoplasms; Prognosis; Proportional hazards models; Time-dependent variables
From: Cancer Research and Clinic 2016;28(5):318-321
CountryChina
Language:Chinese
Abstract: Objective To study the prognostic factors of operative patients with colorectal cancer.Methods Four hundreds and ninety-four patients with colorectal cancer treated from January 2003 to December 2009 in Shanxi Cancer Hospital were involved in this study.The demographic data,clinical and pathological features,serum levels of tumor markers were analyzed retrospectively.The prognostic factors were analyzed by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazards models.Results The 1-,2-,3-,4-,5-year survival rates of 494 patients were 92.31％,69.43 ％,50.00 ％,31.17 ％ and 12.96 ％ respectively.Non-Cox proportional hazards model with time-according to coefficient of multivariate analysis showed that Duke stage,tumor metastasis,pathological diagnosis and serum carcinocmbryonic antigen (CEA) levels were the prognostic factors of colorectal cancer.Conclusion The Duke stage,tumor metastasis,pathological diagnosis and CEA levels are the prognostic factors of colorectal cancer,which should be considered in the choice of clinical treatment and prognosis judgement.