Research progress of checkpoint kinase 1 and DNA damage response pathway in tumors
10.3760/cma.j.issn.1006-9801.2016.04.016
- VernacularTitle:细胞周期监测点激酶1与DNA损伤应答信号通路在肿瘤中的研究进展
- Author:
Yao ZHANG
- Publication Type:Journal Article
- Keywords:
Checkpoint kinase 1;
Breast neoplasms;
DNA damage response pathway
- From:
Cancer Research and Clinic
2016;28(4):279-284
- CountryChina
- Language:Chinese
-
Abstract:
The main reason of recurrence and metastasis in breast cancer is the resistance for the radiotherapy and chemotherapy,and the mechanism of radio-resistance and chemo-resistance may be related to the DNA damage response (DDR).There is a complicated system of the DDR pathway,including cell cycle checkpoint,DNA repair,transcription and apoptosis to maintain the integrity of cell genes.In the cancer treatment,DDR occurs in various kinds of cytotoxic drugs and radiation to cause genetic damage,which limits the curative effect of chemotherapy and radiotherapy.This promotes the targeted therapy of DDR pathway,especially checkpoint kinase 1 (CHK1).Recently,the new viewpoint supports that CHK1 is a main marker of the DDR pathway activation,which shows that CHK1 not only activates the check point but also affects the DNA repair and apoptosis directly.Thus,the role of CHK1 in DDR will promote CHK1 inhibitor to be one of the new treatment strategies for the cancer patients who resist the radiation and chemotherapy.
