Intensive training can relieve post-stroke depression and increase the expression of Kalirin-7 in the hippocampus
10.3760/cma.j.issn.0254-1424.2016.04.001
- VernacularTitle:强化训练对脑卒中后抑郁大鼠抑郁程度及海马区Kalirin-7表达的影响
- Author:
Dawei ZHANG
;
Qiang WANG
;
Jian MA
;
Guangtao BAI
;
Jingjing GAO
;
Ming LI
;
Yangyang GONG
- Publication Type:Journal Article
- Keywords:
Intensive training;
Stroke;
Post-stroke depression
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2016;38(4):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe any effect of intensive training on the degree of depression and the expression of Kalirin-7 in the hippocampus of rats modeling with post-stroke depression,and to investigatc possible mechanisms.Methods Forty male Wistar rats were randomly divided into a post-stroke depression (PSD) group,a routine training group,an intensive training group and a sham-operation group (n =10 for each group).All except the sham-operation group were given the middle cerebral artery occlusion using the intraluminal thread method,and chronic mild stress was applied.The PSD group and the sham-operation group were not given any training.The routine training group was trained oncc a day,and the intensive training group was trained twice a day.The sucrose preference test,open field test and forced swimming test were conducted at the outset and after 14 and 28 days of training.The expression of Kalirin-7 in the left hippocampus was detected using Western blotting.Results After 14 days of training,significant differences were found in the test results of the sham-operation group compared with the other groups (P＜0.05).There were also significant differences in the average results on all 3 tests among all of the groups except the sham-operation group.At both 14 and 28 days after training,the average expression of Kalirin-7 in both the routine and intensive training groups was significantly higher than in the PSD group (P＜0.05),and that of the intensive training group was significantly higher than that of the routine training group at the same time points (P＜0.05).Conclusion Intensive training can relieve depression and increase the expression of the Kalirin-7 in the hippocampus,at least in rats.
