Effects of mannitol and glycerol injection on the experimental intracranial hypertension
10.3760/cma.j.issn.1008-1372.2016.04.017
- VernacularTitle:甘露醇甘油注射液对兔实验性颅内高压的影响
- Author:
Youtian DENG
;
Qing DENG
;
Li MA
;
Guirong ZENG
;
Xiang LIANG
;
Lu ZHANG
- Publication Type:Journal Article
- Keywords:
Mannitol/PD;
Glycerol/PD;
Intracranial hypertension/DT
- From:
Journal of Chinese Physician
2016;18(4):548-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of mannitol and glycerin injection (containing 15％ mannitol and 15％ glycerin) on experimental intracranial hypertension.Methods Rabbits were randomly divided into eight groups (n =8 rabbits/group):normal control group,model control group,mannitol-glycerol injection groups (2.5 ml/kg group,5 ml/kg group,and 10 ml/kg group),compound mannitol injection fluid group,20％ mannitol group,and 10％ glycerol-sodium chloride injection group.The continuous intravenous infusion of nitroglycerin [0.04 mg/(kg · min),10 min] on rabbits was used to establish intracranial hypertension model except the normal control group of animals,and effect of mannitol glycerol injection on it with a single intravenous injection was observed.Serum renal function,electrolytes and other indicators were tested.Results Intravenous infusion of mannitol glycerol injection (2.5 ml/kg,5 ml/kg,and 10 ml/kg) could significantly reduce rabbit nitroglycerin-induced intracranial hypertension,and dosedependent,with increasing dose reducing intracranial pressure could enhance(P ＜ 0.05).Mannitol glycerol injection (5 ml/kg) produced the same intracranial pressure compared to 20％ mannitol and compound mannitol injection,and maintained a long-time role.Conclusions Mannitol glycerin injection can significantly reduce intracranial pressure.Its intensity is the same as 20％ mannitol and compound mannitol injection,and maintains a longer intracranial pressure without significant renal dysfunction and electrolyte distnrhances.
