Association between polymorphism of GIuR6 gene and domestic violence in Uygur population on alcoholics in Xinjiang
10.3760/cma.j.issn.1008-1372.2016.04.009
- VernacularTitle:新疆维吾尔族酒依赖患者家庭暴力行为与谷氨酸受体6基因多态性关联分析
- Author:
Cheng ZHANG
;
Gaiyu TONG
;
Shaohong ZOU
;
Zongfeng ZHAO
;
Hongbing DONG
- Publication Type:Journal Article
- Keywords:
UYGUR NATIONALITY;
Alcohol-related disorders/CO/GE;
Domestic violence;
Receptors,glutamate/GE
- From:
Journal of Chinese Physician
2016;18(4):516-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between glutamate receptor-6 (GIuR6/GRIK2) gene polymorphism and domestic violence in Xinjiang Uygur population on alcoholics.Methods The methods of polymerase chain reaction (PCR) and DNA sequencing technique were conducted to detect rs6922753 and rs2227283 single nucleotide polymorphism of GLUR6 gene in a 104 domestic violence perpetrators on alcoholics and 80 non-domestic violence perpetrators on alcoholics.The association between the polymorphisms and violent behavior was analyzed with SPSS 17.0.Results The frequency of allele (x2 =4.935) and genotype (x2 =7.622) of rs6922753 polymorphisms in the domestic violence group were statistically different from those in the non-domestic violence group (P ＜ 0.05),there was no significant difference between two groups in allele frequencies and genotype in rs2227283 site (P ＞ 0.05).Conclusions GIuR6 gene polymorphism may be associated with domestic violence in Xinjiang Uygur population on alcoholics.
