The expressions of IL-33 and ST2 receptor in nervous system and their roles in pain
10.3760/cma.j.issn.1008-1372.2016.04.008
- VernacularTitle:IL-33及其ST2受体在神经系统中的表达及其介入疼痛相关疾病的研究进展
- Author:
Bo ZHOU
;
Jiangang LUO
;
Jianqin YAN
- Publication Type:Journal Article
- Keywords:
Interleukin-1/ME;
Receptors,interleukin-1/ME;
Nervous system/ME;
Pain/ME;
Review
- From:
Journal of Chinese Physician
2016;18(4):512-515
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-33 (IL-33),a novel member of IL-1 family,is a multifunctional cytokine.IL-33 can act as a transcriptional repressor.It can also bind to growth stimulation expressed gene 2 protein (ST2) to induce the activation of some inflammatory cells.IL-33 is extensively expressed in nervous system.Some studies showed that the levels of IL-33 and ST2 were significantly changed in pain.Some reports demonstrated that the IL-33/ST2 signaling pathway played critical roles in them.This present article will review the biological characteristics of IL-33/ST2 and their expressions in nervous system and significance of interventional pain related diseases.
